Medicinal Genomic’s Jane-Ome application provides users with exclusive genomic information on various Cannabis genomes. The ipad application provides users with access to several scientific news feeds that explore the science of medicinal Cannabis, making Jane-Ome the nerve center to explore the plant’s therapeutic potential. In addition to its encyclopedic information about the bleeding-edge science of Cannabis, Jane-Ome users can compete in Cannabis related trivia to earn the right to guide future sequencing efforts. Users can also explore never before released blueprints for the equipment used to crack the human genome project, as well as access videos which explain the impact DNA sequencing and genomics have had on the world. Furthermore, Jane-Ome provides users with access to never before seen videos documenting the history of the human genome project, as well as commentary from members of that scientific consortium explaining how research has led them to aim their sights on unlocking the genome of Cannabis. Complete with sound tracks courtesy of Slightly Stoopid, The Jane-Ome is a must have for anyone trying to teach other people about the value of the worlds more versatile plant.

MaryJanes Genome Is Live on the Apple iStore.

Credits:

Jane-Ome Genome Brower

The build in genome browser contains the polymorphisms found in the cannabinoid synthesis pathways of all sequenced Cannabis plants to date.  There are also videos which help introduce genomics to layman and touch on how synthetic biology and genomics may transform our understanding of this plants interaction with humans.

Jane-Ome Data Feeds

We are on a hunt for genes involved in cannabinoid synthesis. One such non-psychoactive therapeutic cannabinoid is Cannabichromene. Although plants which make this predominant cannabinoid have been bred, its still unclear which genetic pathway is responsible for this and how it is regulated in respect to the other cannabinoid synthase genes. Sequencing the genomes of multiple related plants is likely required to tease apart the polymorphisms in the genomes to make better sense of the genomic architecture. Although many have feared our work as enabling high THC genetics, its our opinion that prohibition has already accomplished this by the use of weight only based prosecution (hence demand for more potent THC per weight) and we are very late to this game. Since all of the cannabinoids and terpenes share a common GPP precursor, selection for high THC genetics will come at the cost of other therapeutic non-psychoactive cannabinoids being bred to extinction levels. We are interested in reversing this trend and bringing many of the non-psychoactive therapeutic cannabinoids back into the gene pool. The most current pharmacology does not suggest to pursue this goal to the extreme.  The elimination of THC (otherwise known as hemp) is a poor therapeutic plan as THC combined with other cannabinoids at equal concentrations has proven to have the highest efficacy and many of the non-psychoactive cannabinoids like CBD attenuate the psychoactive effects of THC when co-administered (Marcu)(Fairbairn and Pickens). Two hemp strains have been sequenced by Van Bakel et al (Finola and USO-31). Finola is a high CBDA strain. Between now and April 20th 2012 we will be releasing new links in Jane-Ome for access to data from more cultivars. It will initially be in raw read form (large files). Potentially some SNP files and genome browser updates. In addition, the most current LA Confidential assembly will be made public as well. Be certain to refresh your access data button to see more links. These links must be accessed from a PC or a Mac as the files are too large to download to an iPad. The bandwidth costs we absorb far exceed the cost of the I-Pad app so please be courteous with the downloads or we will have to shut this down. Please encourage others to buy the app so we can continue to fund the bandwidth costs and as always please help us with feedback via reviews in iTunes. There will be a rotating password to the site to prevent abuse but we’re certain you can out smart us on this one so we ask for your courtesy and support of the project.

Cultivars being featured:

LA Confidential (DNA Genetics) with 454 long reads and assembly by Newbler. Below are all short insert ILMN 2x100bp reads with Nextera, Whole genome shotgun performed to 5-20X coverage.These are short inserts with reads which overlap. No Error correction or read extentions have been attempted with these datasets.

LA Confidential  (DNA Genetics) with 2×100 HiSeq reads via Nextera Library preparations.

Green House Seeds
Green House Seeds

Green Crack  (GreenHouse Seeds). Skunk#1 crossed with Afgani. Winner of several harvest festivals, and “High Times” Cannabis Cup. Skunk#1 (75% Sativa, 25% Indica) was originally a cross between 25% Afghani, 25% Mexican Acapulco Gold and 50% Columbian Gold. Inbred since 1978

LA Confidential x Cannadential
LA Confidential x Cannadential

RECON (DNA Genetics). LA Confidential X Cannadential. Cannadential = LA Confidential X Cannalope Haze. Cannalope Haze = Haze Brothers X Mexican. Should make an interesting strain to compare to LA Confidential.

OG Kush x Train Wreck (T4)
OG Kush x Train Wreck (T4)

Kandy Kush (DNA Genetics). OG Kush X Trainwreck.

OG Chocolate Thai x Cannalope Haze
OG Chocolate Thai x Cannalope Haze

Chocolope (DNA Genetics). Cannalope Male X OG Chocolate Thai Female.

Bag seed from a Grateful Dead show (Chem Dawg)
Bag seed from a Grateful Dead show (Chem Dawg)

OG Kush- Comparison to Chemdawg should be interesting. Urban lore has OG Kush as an alias for ChemDawg. Perhaps the DNA sequence will end the debate.


LICENSE- The sequence data provided in the I-Pad App is creative commons. Enjoy.