THCA Metabolism

Majority pathway

 

Drug test vary on which metabolite they screen for. Only delta 9 THC produces impairment while 11-COOH-THC can be in your system for weeks to months. More accurate tests measure the ratio of 11-OH-THC to 11-COOH-THC to predict time since impairment with delta 9-THC.

CYP2C9 is a p450 cyctochrome gene which is thought to metabolize these compounds. DNA polymorphisms in this gene have are predictive of Warfarin sensitivity and are likely important to other drug metabolism.

 

 

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  • carnosine eye drops

    if only 11-COOH-THC is present then the cannabis was used some time ago and any impairment in cognitive ability or motor function will have dissipated, whereas if both 11-OH-THC and 11-COOH-THC are present then the cannabis was consumed more recently and motor impairment may still be present.

  • corporations offshore

    Unfortunately, in the present study, blood could only be collected for seven days, an insufficient period for total THC elimination in nine of 18 heavy cannabis users participating in this in-patient research study. At the time, it was difficult to justify seven days of blood collection to the ethical review committees due to the belief that THC would be rapidly eliminated, as occurs within hours of acute exposure in occasional cannabis users. Past research conducted in our laboratory showed that THC concentrations decreased rapidly and fell below quantification limits in approximately 12.5 ± 3.1 h after a 3.55% THC cigarette ( 13 ). Also, mean THC concentrations were only 0.86 ± 0.22 ng/mL in chronic users 12 h after last cannabis use in a study by Peat et al. ( 14 ). A 13-day THC detection period was described for three chronic cannabis smokers administered 60 mg THC over a 2-day period ( 12 ). However, the analytical method did not report qualifier ions, LOQ, or other method validation parameters for the few specimens analyzed by GC–MS. More recently, participants resided on the closed research unit for as long as 30 days of abstinence with collection of all urine specimens. Urine specimens were specially hydrolyzed with E. coli β-glucuronidase to analyze free THC and 11-OH-THC ( 25 ). We found measurable THC (≥ 2.5 ng/mL) in urine up to 24 days after initiation of abstinence on a closed research unit with 24 h monitoring ( 26 ). These urine results in conjunction with our plasma THC data suggest that residual THC in the brain could be responsible for noted neurocognitive impairment following heavy, frequent cannabis use.